Assay Detail
Functional
CHEMBL4687065
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SMMC-7721 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel NF-кB inhibitor based on scaffold hopping: 1,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 55 | 5.11 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.85 |
| CHEMBL4750129 | — | — | 1 | 5.62 |
| CHEMBL4741179 | — | — | 1 | 5.46 |
| CHEMBL4746128 | — | — | 1 | 5.42 |
| CHEMBL1255036 | — | — | 1 | 5.39 |
| CHEMBL4742986 | — | — | 1 | 5.38 |
| CHEMBL4799155 | — | — | 1 | 5.38 |
| CHEMBL4781217 | — | — | 1 | 5.37 |
| CHEMBL4745842 | — | — | 1 | 5.36 |
| CHEMBL4746913 | — | — | 1 | 5.35 |
| CHEMBL4794947 | — | — | 1 | 5.35 |
| CHEMBL4754107 | — | — | 1 | 5.32 |
| CHEMBL4778745 | — | — | 1 | 5.31 |
| CHEMBL4793217 | — | — | 1 | 5.30 |
| CHEMBL4745891 | — | — | 1 | 5.30 |
| CHEMBL4751084 | — | — | 1 | 5.28 |
| CHEMBL4763287 | — | — | 1 | 5.28 |
| CHEMBL4761790 | — | — | 1 | 5.26 |
| CHEMBL4744650 | — | — | 1 | 5.24 |
| CHEMBL4796590 | — | — | 1 | 5.24 |
| CHEMBL4788021 | — | — | 1 | 5.21 |
| CHEMBL4783441 | — | — | 1 | 5.21 |
| CHEMBL4755953 | — | — | 1 | 5.20 |
| CHEMBL4764853 | — | — | 1 | 5.19 |
| CHEMBL4759359 | — | — | 1 | 5.16 |
| CHEMBL4750115 | — | — | 1 | 5.14 |
| CHEMBL4166712 | — | — | 1 | 5.12 |
| CHEMBL4165653 | — | — | 1 | 5.11 |
| CHEMBL4756893 | — | — | 1 | 5.11 |
| CHEMBL4786617 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4750129 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4741179 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4746128 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1255036 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4742986 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4799155 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4781217 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4745842 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4746913 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4794947 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4754107 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4778745 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4745891 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4793217 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4751084 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4763287 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4761790 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4744650 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4796590 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4788021 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4783441 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4755953 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4764853 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4759359 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4750115 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4166712 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4165653 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4756893 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4786617 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4765222 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4757972 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4748146 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4786668 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4745771 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL4786560 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4785202 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4754377 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL4760481 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4784597 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4752043 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4786360 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL4791465 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4743704 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL4751480 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL4755731 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL4788735 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL4745370 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL4761347 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL4764765 | — | IC50 | = | 15000.0 | nM | 4.82 |