Assay Detail
ADMET
CHEMBL4687066
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Cytotoxicity against human HHL-5 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HHL-5 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel NF-кB inhibitor based on scaffold hopping: 1,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 55 | 4.84 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4745891 | — | — | 1 | 5.22 |
| CHEMBL4783441 | — | — | 1 | 5.18 |
| CHEMBL4794947 | — | — | 1 | 5.12 |
| CHEMBL4793217 | — | — | 1 | 5.11 |
| CHEMBL4748146 | — | — | 1 | 5.11 |
| CHEMBL1255036 | — | — | 1 | 5.10 |
| CHEMBL4778745 | — | — | 1 | 5.04 |
| CHEMBL4750115 | — | — | 1 | 5.02 |
| CHEMBL4746913 | — | — | 1 | 5.02 |
| CHEMBL4765222 | — | — | 1 | 5.00 |
| CHEMBL4749315 | — | — | 1 | 4.99 |
| CHEMBL4796590 | — | — | 1 | 4.97 |
| CHEMBL4764853 | — | — | 1 | 4.97 |
| CHEMBL4756893 | — | — | 1 | 4.97 |
| CHEMBL4742846 | — | — | 1 | 4.96 |
| CHEMBL4794672 | — | — | 1 | 4.95 |
| CHEMBL4751480 | — | — | 1 | 4.95 |
| CHEMBL4786617 | — | — | 1 | 4.94 |
| CHEMBL4745370 | — | — | 1 | 4.93 |
| CHEMBL4761790 | — | — | 1 | 4.92 |
| CHEMBL4786560 | — | — | 1 | 4.92 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 4.91 |
| CHEMBL4745771 | — | — | 1 | 4.90 |
| CHEMBL4755953 | — | — | 1 | 4.89 |
| CHEMBL4754107 | — | — | 1 | 4.89 |
| CHEMBL4166712 | — | — | 1 | 4.87 |
| CHEMBL4788735 | — | — | 1 | 4.87 |
| CHEMBL4799155 | — | — | 1 | 4.87 |
| CHEMBL4751084 | — | — | 1 | 4.85 |
| CHEMBL4761347 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4745891 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4783441 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4794947 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4793217 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4748146 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1255036 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4778745 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4750115 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4746913 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4765222 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4749315 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4756893 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL4764853 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL4796590 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL4742846 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL4794672 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL4751480 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4786617 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL4745370 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4761790 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4786560 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4745771 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL4755953 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4754107 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL4166712 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL4799155 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL4788735 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL4751084 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4761347 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL4165653 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL4764765 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL4763287 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL4786668 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4755731 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL4745842 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL4784597 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL4785202 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4754377 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4743704 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4759359 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL4791465 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL4742986 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL4741179 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL4757972 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL4760481 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL4746128 | — | IC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL4744650 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL4752043 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL4783835 | — | IC50 | = | 26700.0 | nM | 4.57 |