Assay Detail
Functional
CHEMBL4687166
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Antiproliferative activity against human HGC-27 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HGC-27 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thiosemicarbazone-based lead optimization to discover high-efficiency and low-toxicity anti-gastric cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.74 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2203744 | — | — | 1 | 7.16 |
| CHEMBL3250290 | — | — | 1 | 6.18 |
| CHEMBL3250265 | — | — | 1 | 6.07 |
| CHEMBL3250291 | — | — | 1 | 5.56 |
| CHEMBL3250292 | — | — | 1 | 5.38 |
| CHEMBL231616 | TRIAPINE | 3.0 | 1 | 4.94 |
| CHEMBL4743095 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2203744 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3250290 | — | IC50 | = | 654.0 | nM | 6.18 |
| CHEMBL3250265 | — | IC50 | = | 846.0 | nM | 6.07 |
| CHEMBL3250291 | — | IC50 | = | 2764.0 | nM | 5.56 |
| CHEMBL3250292 | — | IC50 | = | 4172.0 | nM | 5.38 |
| CHEMBL231616 | TRIAPINE | IC50 | = | 11495.0 | nM | 4.94 |
| CHEMBL4743095 | — | IC50 | = | 13934.0 | nM | 4.86 |