Assay Detail
Binding
CHEMBL4687623
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CD39 using ATP as substrate preincubated for 3 mins followed by substrate addition and measured after 10 to 15 mins by Malachite green reagent based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ectonucleoside triphosphate diphosphohydrolase 1 (CHEMBL5722) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting Metabolism of Extracellular Nucleotides via Inhibition of Ectonucleotidases CD73 and CD39.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.75 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2364580 | — | — | 1 | 5.25 |
| CHEMBL4797422 | — | — | 1 | 4.55 |
| CHEMBL4750781 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2364580 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4797422 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4750781 | — | IC50 | = | 35000.0 | nM | 4.46 |