Assay Detail
Binding
CHEMBL4687630
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human NTPDase3 expressed in green monkey Cos-7 cells using ATP as substrate preincubated for 3 mins followed by substrate addition by malachite green reagent based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ectonucleoside triphosphate diphosphohydrolase 3 (CHEMBL5897) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting Metabolism of Extracellular Nucleotides via Inhibition of Ectonucleotidases CD73 and CD39.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.80 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4787368 | — | — | 1 | 6.22 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4787368 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL265502 | SURAMIN | IC50 | = | 4300.0 | nM | 5.37 |