Assay Detail
Binding
CHEMBL4687755
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Agonist activity at TLR2 in HEK-Blue hTLR2 cells assessed as NF-kappaB activation preincubated for 24 hrs followed by replacement of medium containing compound and measured after 0.5 to 1 hrs by Quanti-blue SEAP assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-Blue hTLR2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modulation of the Innate Immune Response by Targeting Toll-like Receptors: A Perspective on Their Agonists and Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.29 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4759149 | — | — | 1 | 8.31 |
| CHEMBL4581678 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4759149 | — | EC50 | = | 4.88 | nM | 8.31 |
| CHEMBL4581678 | — | EC50 | = | 550.0 | nM | 6.26 |