Assay Detail
Functional
CHEMBL4687993
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
10-(4-Phenylpiperazine-1-carbonyl)acridin-9(10H)-ones and related compounds: Synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 6.55 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376464 | — | — | 1 | 7.92 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.89 |
| CHEMBL4787025 | — | — | 1 | 7.89 |
| CHEMBL4793009 | — | — | 1 | 7.58 |
| CHEMBL4747156 | — | — | 1 | 7.50 |
| CHEMBL4757163 | — | — | 1 | 7.42 |
| CHEMBL4745927 | — | — | 1 | 7.41 |
| CHEMBL4776218 | — | — | 1 | 7.35 |
| CHEMBL4790475 | — | — | 1 | 7.26 |
| CHEMBL4779308 | — | — | 1 | 7.22 |
| CHEMBL4754175 | — | — | 1 | 7.05 |
| CHEMBL4748250 | — | — | 1 | 6.72 |
| CHEMBL4751544 | — | — | 1 | 6.72 |
| CHEMBL4787150 | — | — | 1 | 6.70 |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 6.66 |
| CHEMBL4782623 | — | — | 1 | 6.64 |
| CHEMBL4761079 | — | — | 1 | 6.48 |
| CHEMBL4756856 | — | — | 1 | 6.41 |
| CHEMBL4783999 | — | — | 1 | 6.36 |
| CHEMBL4788530 | — | — | 1 | 6.21 |
| CHEMBL4763232 | — | — | 1 | 6.17 |
| CHEMBL4799230 | — | — | 1 | 6.08 |
| CHEMBL4743548 | — | — | 1 | 6.05 |
| CHEMBL4785373 | — | — | 1 | 5.96 |
| CHEMBL4748186 | — | — | 1 | 5.89 |
| CHEMBL4779146 | — | — | 1 | 5.89 |
| CHEMBL4756819 | — | — | 1 | 5.89 |
| CHEMBL4776101 | — | — | 1 | 5.89 |
| CHEMBL4779398 | — | — | 1 | 5.52 |
| CHEMBL4798561 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376464 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL107 | COLCHICINE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4787025 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4793009 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4747156 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4757163 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4745927 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4776218 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4790475 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4779308 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4754175 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4751544 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4748250 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4787150 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4782623 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4761079 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4756856 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4783999 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4788530 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4763232 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4799230 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4743548 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4785373 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4748186 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4779146 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4756819 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4776101 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4779398 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4798561 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4795030 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4751743 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4746418 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4755843 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4762635 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4793429 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4747192 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4758048 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4740698 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4795557 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4794320 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4750110 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4794202 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180145 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4800242 | — | IC50 | > | 10000.0 | nM | - |