Assay Detail
Binding
CHEMBL4688056
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcine pancreatic lipase preincubated for 10 mins followed by 4-MUO addition and measured at 60 sec interval for 40 mins by multi plate micro plate reader
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel chalcone-like compounds as potent and reversible pancreatic lipase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.16 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365190 | — | — | 1 | 8.33 |
| CHEMBL4780197 | — | — | 1 | 6.48 |
| CHEMBL4788400 | — | — | 1 | 6.24 |
| CHEMBL4797179 | — | — | 1 | 6.17 |
| CHEMBL4782276 | — | — | 1 | 6.08 |
| CHEMBL4748399 | — | — | 1 | 5.77 |
| CHEMBL4757866 | — | — | 1 | 5.68 |
| CHEMBL4744746 | — | — | 1 | 5.60 |
| CHEMBL4752404 | — | — | 1 | 5.59 |
| CHEMBL4740149 | — | — | 1 | 5.48 |
| CHEMBL4776624 | — | — | 1 | 5.46 |
| CHEMBL4761197 | — | — | 1 | 5.16 |
| CHEMBL4745825 | — | — | 1 | 5.07 |
| CHEMBL4747287 | — | — | 1 | 4.98 |
| CHEMBL4751728 | — | — | 1 | 4.91 |
| CHEMBL4160838 | — | — | 1 | 4.83 |
| CHEMBL4778007 | — | — | 1 | 4.83 |
| CHEMBL4080900 | — | — | 1 | 4.83 |
| CHEMBL4780689 | — | — | 1 | 4.68 |
| CHEMBL4765140 | — | — | 1 | 4.61 |
| CHEMBL4750178 | — | — | 1 | 4.60 |
| CHEMBL4098933 | — | — | 1 | 4.54 |
| CHEMBL4086755 | — | — | 1 | 4.49 |
| CHEMBL4742119 | — | — | 1 | 4.46 |
| CHEMBL4756815 | — | — | 1 | 4.43 |
| CHEMBL4779689 | — | — | 1 | 4.12 |
| CHEMBL4091194 | — | — | 1 | 4.12 |
| CHEMBL4747550 | — | — | 1 | 4.08 |
| CHEMBL7976 | CHALCONE | — | 1 | 4.07 |
| CHEMBL4078900 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365190 | — | IC50 | = | 4.65 | nM | 8.33 |
| CHEMBL4780197 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4788400 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4797179 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4782276 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4748399 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL4757866 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL4744746 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL4752404 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL4740149 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL4776624 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4761197 | — | IC50 | = | 6940.0 | nM | 5.16 |
| CHEMBL4745825 | — | IC50 | = | 8610.0 | nM | 5.07 |
| CHEMBL4747287 | — | IC50 | = | 10420.0 | nM | 4.98 |
| CHEMBL4751728 | — | IC50 | = | 12360.0 | nM | 4.91 |
| CHEMBL4778007 | — | IC50 | = | 14790.0 | nM | 4.83 |
| CHEMBL4080900 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL4160838 | — | IC50 | = | 14890.0 | nM | 4.83 |
| CHEMBL4780689 | — | IC50 | = | 20660.0 | nM | 4.68 |
| CHEMBL4765140 | — | IC50 | = | 24810.0 | nM | 4.61 |
| CHEMBL4750178 | — | IC50 | = | 25090.0 | nM | 4.60 |
| CHEMBL4098933 | — | IC50 | = | 28930.0 | nM | 4.54 |
| CHEMBL4086755 | — | IC50 | = | 32670.0 | nM | 4.49 |
| CHEMBL4742119 | — | IC50 | = | 35010.0 | nM | 4.46 |
| CHEMBL4756815 | — | IC50 | = | 37150.0 | nM | 4.43 |
| CHEMBL4779689 | — | IC50 | = | 75380.0 | nM | 4.12 |
| CHEMBL4091194 | — | IC50 | = | 75580.0 | nM | 4.12 |
| CHEMBL4747550 | — | IC50 | = | 84090.0 | nM | 4.08 |
| CHEMBL7976 | CHALCONE | IC50 | = | 84410.0 | nM | 4.07 |
| CHEMBL4078900 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4785507 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4170979 | — | IC50 | > | 100000.0 | nM | - |