Assay Detail
Binding
CHEMBL4688701
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rabbit skeletal muscle myosin-2 ATPase incubated for 20 mins followed by ATP addition and measured after 20 mins
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Skeletal muscle tissue |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Myosin light chain kinase 2, skeletal/cardiac muscle (CHEMBL4739674) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
In vitro and in vivo effects of inhibitors on actin and myosin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 1 | - | - |
| IC50 | 1 | 5.29 | 5.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1235156 | PENTABROMOPSEUDILIN | — | 1 | 5.29 |
| CHEMBL1738815 | PENTACHLOROPSEUDILIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1235156 | PENTABROMOPSEUDILIN | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1738815 | PENTACHLOROPSEUDILIN | Inhibition | - | % | - |