Assay Detail
Binding
CHEMBL4688848
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse CD73
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of natural product ellagic acid as a potent CD73 and CD39 dual inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.68 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6246 | ELLAGIC ACID | 2.0 | 1 | 7.40 |
| CHEMBL583969 | PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | — | 1 | 5.33 |
| CHEMBL23236 | BETULIN | — | 1 | 4.30 |
| CHEMBL382408 | PENTAGALLOYL GLUCOSE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6246 | ELLAGIC ACID | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL583969 | PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | IC50 | = | 4630.0 | nM | 5.33 |
| CHEMBL23236 | BETULIN | IC50 | = | 50320.0 | nM | 4.30 |
| CHEMBL382408 | PENTAGALLOYL GLUCOSE | IC50 | > | 100000.0 | nM | - |