Assay Detail
Functional
CHEMBL4689209
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of DB18, a potent inhibitor of CLK kinases with a high selectivity against DYRK1A kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.78 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.52 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.16 |
| CHEMBL4783398 | — | — | 1 | 5.40 |
| CHEMBL4761834 | — | — | 1 | 5.30 |
| CHEMBL4795706 | — | — | 1 | 5.22 |
| CHEMBL4751143 | — | — | 1 | 5.22 |
| CHEMBL4754002 | — | — | 1 | 5.10 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 5.05 |
| CHEMBL4793064 | — | — | 1 | 5.05 |
| CHEMBL4760556 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4783398 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4761834 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4795706 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4751143 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4754002 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4793064 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4760556 | — | IC50 | > | 25000.0 | nM | - |