Assay Detail
ADMET
CHEMBL4689210
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Cytotoxicity against human Fibroblast cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Fibroblast |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of DB18, a potent inhibitor of CLK kinases with a high selectivity against DYRK1A kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.63 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.82 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.00 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 5.22 |
| CHEMBL4761834 | — | — | 1 | 5.10 |
| CHEMBL4795706 | — | — | 1 | 4.85 |
| CHEMBL4754002 | — | — | 1 | 4.75 |
| CHEMBL4783398 | — | — | 1 | 4.68 |
| CHEMBL4751143 | — | — | 1 | - |
| CHEMBL4793064 | — | — | 1 | - |
| CHEMBL4760556 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4761834 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4795706 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4754002 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4783398 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4751143 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4793064 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4760556 | — | IC50 | > | 25000.0 | nM | - |