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Assay Detail

CHEMBL4689474

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against West Nile virus infected in african green monkey Vero E6 cells assessed as virus titer reduction incubated for 48 hrs by plaque assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism West Nile virus
Cell Type Vero 76
Confidence 1 — Organism
Curated By Autocuration

Target

West Nile virus (CHEMBL613730)
Type ORGANISM
Organism West Nile virus

Publication

The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin.
Lam van TV,Heindl MR,Schlutt C,Böttcher-Friebertshäuser E,Bartenschlager R,Klebe G,Brandstetter H,Dahms SO,Steinmetzer T
ACS Med Chem Lett (2021) 12 : 426 -432
PubMed 33732412 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 2 5.94 6.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4759036 1 6.04
CHEMBL4790628 1 5.84

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4759036 EC50 = 910.0 nM 6.04
CHEMBL4790628 EC50 = 1460.0 nM 5.84