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Assay Detail

CHEMBL4689537

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Binding
Inhibition of HDAC2 (unknown origin) using compound purified by microgram-scale HPLC work-flow
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone deacetylase 2 (CHEMBL1937)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis of HDAC Inhibitor Libraries via Microscale Workflow.
Dykstra KD,Streckfuss E,Liu M,Liu J,Yu Y,Wang M,Kozlowski JA,Myers RW,Buevich AV,Maletic MM,Vachal P,Krska SW
ACS Med Chem Lett (2021) 12 : 337 -342
PubMed 33738059 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 36 7.27 8.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4780974 1 8.85
CHEMBL4753452 1 8.74
CHEMBL4792257 1 8.70
CHEMBL4745088 1 8.64
CHEMBL4758559 1 8.04
CHEMBL4759606 1 8.03
CHEMBL4754237 1 7.85
CHEMBL4747553 1 7.80
CHEMBL4754365 1 7.75
CHEMBL4748516 1 7.75
CHEMBL4751762 1 7.60
CHEMBL4793832 1 7.57
CHEMBL4794196 1 7.57
CHEMBL4753648 1 7.47
CHEMBL4788187 1 7.41
CHEMBL4757813 1 7.37
CHEMBL4753639 1 7.25
CHEMBL4797791 1 7.21
CHEMBL4794888 1 7.20
CHEMBL4781134 1 7.19
CHEMBL4761389 1 7.16
CHEMBL4756846 1 7.16
CHEMBL4753460 1 7.12
CHEMBL4755946 1 7.06
CHEMBL4759915 1 7.04
CHEMBL4753036 1 6.88
CHEMBL4793261 1 6.81
CHEMBL4745945 1 6.60
CHEMBL4752037 1 6.55
CHEMBL4789871 1 6.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4780974 IC50 = 1.4 nM 8.85
CHEMBL4753452 IC50 = 1.8 nM 8.74
CHEMBL4792257 IC50 = 2.0 nM 8.70
CHEMBL4745088 IC50 = 2.3 nM 8.64
CHEMBL4758559 IC50 = 9.1 nM 8.04
CHEMBL4759606 IC50 = 9.4 nM 8.03
CHEMBL4754237 IC50 = 14.0 nM 7.85
CHEMBL4747553 IC50 = 16.0 nM 7.80
CHEMBL4754365 IC50 = 18.0 nM 7.75
CHEMBL4748516 IC50 = 18.0 nM 7.75
CHEMBL4751762 IC50 = 25.0 nM 7.60
CHEMBL4793832 IC50 = 27.0 nM 7.57
CHEMBL4794196 IC50 = 27.0 nM 7.57
CHEMBL4753648 IC50 = 34.0 nM 7.47
CHEMBL4788187 IC50 = 39.0 nM 7.41
CHEMBL4757813 IC50 = 43.0 nM 7.37
CHEMBL4753639 IC50 = 56.0 nM 7.25
CHEMBL4797791 IC50 = 62.0 nM 7.21
CHEMBL4794888 IC50 = 63.0 nM 7.20
CHEMBL4781134 IC50 = 64.0 nM 7.19
CHEMBL4761389 IC50 = 70.0 nM 7.16
CHEMBL4756846 IC50 = 70.0 nM 7.16
CHEMBL4753460 IC50 = 76.0 nM 7.12
CHEMBL4755946 IC50 = 87.0 nM 7.06
CHEMBL4759915 IC50 = 92.0 nM 7.04
CHEMBL4753036 IC50 = 133.0 nM 6.88
CHEMBL4793261 IC50 = 154.0 nM 6.81
CHEMBL4745945 IC50 = 249.0 nM 6.60
CHEMBL4752037 IC50 = 279.0 nM 6.55
CHEMBL4789871 IC50 = 320.0 nM 6.50
CHEMBL4755945 IC50 = 370.0 nM 6.43
CHEMBL4765072 IC50 = 491.0 nM 6.31
CHEMBL4754717 IC50 = 583.0 nM 6.23
CHEMBL4637357 IC50 = 749.0 nM 6.13
CHEMBL4799996 IC50 = 1553.0 nM 5.81
CHEMBL4755112 IC50 = 1664.0 nM 5.78