Assay Detail
ADMET
CHEMBL4689596
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Inhibition of Class 1/2b HDAC in human Jurkat E6.1 cells using Boc-Lys-(Ac)-AMC as substrate by fluorogenic assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Jurkat E6.1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.28 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4760047 | — | — | 1 | 6.28 |
| CHEMBL4754665 | — | — | 1 | 5.82 |
| CHEMBL4744030 | — | — | 1 | 5.77 |
| CHEMBL3692671 | — | — | 1 | 5.52 |
| CHEMBL4753102 | — | — | 1 | 5.44 |
| CHEMBL4747488 | — | — | 1 | 5.43 |
| CHEMBL4798111 | — | — | 1 | 5.30 |
| CHEMBL4740322 | — | — | 1 | 5.19 |
| CHEMBL3692665 | — | — | 1 | 5.05 |
| CHEMBL3692664 | — | — | 1 | 5.00 |
| CHEMBL4797931 | — | — | 1 | 4.99 |
| CHEMBL4753030 | — | — | 1 | 4.92 |
| CHEMBL4764348 | — | — | 1 | 4.85 |
| CHEMBL3910908 | — | — | 1 | 4.37 |
| CHEMBL4752150 | — | — | 1 | - |
| CHEMBL4752226 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4760047 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4754665 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4744030 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3692671 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4753102 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4747488 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4798111 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4740322 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3692665 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3692664 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4797931 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4753030 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4764348 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3910908 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4752150 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4752226 | — | IC50 | > | 50000.0 | nM | - |