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Assay Detail

CHEMBL4689604

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Class 2A HDAC in human HEK293 cells using Boc-Lys(TFA) as substrate by fluorogenic assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease.
Stott AJ,Maillard MC,Beaumont V,Allcock D,Aziz O,Borchers AH,Blackaby W,Breccia P,Creighton-Gutteridge G,Haughan AF,Jarvis RE,Luckhurst CA,Matthews KL,McAllister G,Pollack S,Saville-Stones E,Van de Poël AJ,Vater HD,Vann J,Williams R,Yates D,Muñoz-Sanjuán I,Dominguez C
ACS Med Chem Lett (2021) 12 : 380 -388
PubMed 33738065 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 8.00 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4798111 1 8.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4798111 IC50 = 10.0 nM 8.00