Assay Detail
Binding
CHEMBL4689679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as reduction in kynurenine production using L-Tryptophan as substrate incubated for 48 hrs by fluorescence based assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.83 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4764710 | — | — | 1 | 9.10 |
| CHEMBL4744727 | — | — | 1 | 8.85 |
| CHEMBL4755227 | — | — | 1 | 8.80 |
| CHEMBL4779920 | — | — | 1 | 8.77 |
| CHEMBL4783395 | — | — | 1 | 8.74 |
| CHEMBL4749009 | — | — | 1 | 8.59 |
| CHEMBL4744926 | — | — | 1 | 8.52 |
| CHEMBL4788473 | — | — | 1 | 8.52 |
| CHEMBL4779248 | — | — | 1 | 8.42 |
| CHEMBL4799004 | — | — | 1 | 8.30 |
| CHEMBL4780616 | — | — | 1 | 8.15 |
| CHEMBL4777831 | — | — | 1 | 8.11 |
| CHEMBL4791214 | — | — | 1 | 8.05 |
| CHEMBL4636709 | — | — | 1 | 8.02 |
| CHEMBL4789491 | — | — | 1 | 8.00 |
| CHEMBL4764265 | — | — | 1 | 7.82 |
| CHEMBL4748177 | — | — | 1 | 7.80 |
| CHEMBL4757898 | — | — | 1 | 7.72 |
| CHEMBL4762148 | — | — | 1 | 7.70 |
| CHEMBL4747995 | — | — | 1 | 7.66 |
| CHEMBL4750629 | — | — | 1 | 7.62 |
| CHEMBL4788204 | — | — | 1 | 7.60 |
| CHEMBL4799199 | — | — | 1 | 7.52 |
| CHEMBL4747474 | — | — | 1 | 7.05 |
| CHEMBL4788767 | — | — | 1 | 7.03 |
| CHEMBL4761407 | — | — | 1 | 6.55 |
| CHEMBL4757764 | — | — | 1 | 6.52 |
| CHEMBL4777112 | — | — | 1 | 5.89 |
| CHEMBL4756334 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4764710 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4744727 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4755227 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4779920 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4783395 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4749009 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4744926 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4788473 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4779248 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4799004 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4780616 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4777831 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4791214 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4636709 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL4789491 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4764265 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4748177 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4757898 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4762148 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4747995 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4750629 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4788204 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4799199 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4747474 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4788767 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4761407 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL4757764 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL4777112 | — | IC50 | = | 1277.0 | nM | 5.89 |
| CHEMBL4756334 | — | IC50 | = | 1697.0 | nM | 5.77 |