Assay Detail
Binding
CHEMBL4689681
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [35S]-MK499 binding to human ERG expressed in HEK293 cells incubated for 2 hrs by liquid scintillation counting method
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.86 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747474 | — | — | 1 | 6.14 |
| CHEMBL4799004 | — | — | 1 | 6.00 |
| CHEMBL4788204 | — | — | 1 | 6.00 |
| CHEMBL4744926 | — | — | 1 | 5.16 |
| CHEMBL4755227 | — | — | 1 | 5.06 |
| CHEMBL4791214 | — | — | 1 | 4.96 |
| CHEMBL4777831 | — | — | 1 | 4.80 |
| CHEMBL4779248 | — | — | 1 | 4.75 |
| CHEMBL4749009 | — | — | 1 | 4.70 |
| CHEMBL4750629 | — | — | 1 | 4.70 |
| CHEMBL4779920 | — | — | 1 | 4.70 |
| CHEMBL4748177 | — | — | 1 | 4.66 |
| CHEMBL4744727 | — | — | 1 | 4.64 |
| CHEMBL4788767 | — | — | 1 | 4.62 |
| CHEMBL4783395 | — | — | 1 | 4.60 |
| CHEMBL4764710 | — | — | 1 | 4.22 |
| CHEMBL4636709 | — | — | 1 | 4.22 |
| CHEMBL4788473 | — | — | 1 | 4.22 |
| CHEMBL4747995 | — | — | 1 | 4.22 |
| CHEMBL4789491 | — | — | 1 | - |
| CHEMBL4761407 | — | — | 1 | - |
| CHEMBL4757898 | — | — | 1 | - |
| CHEMBL4756334 | — | — | 1 | - |
| CHEMBL4757764 | — | — | 1 | - |
| CHEMBL4799199 | — | — | 1 | - |
| CHEMBL4762148 | — | — | 1 | - |
| CHEMBL4777112 | — | — | 1 | - |
| CHEMBL4780616 | — | — | 1 | - |
| CHEMBL4764265 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747474 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4799004 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4788204 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4744926 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4755227 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL4791214 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4777831 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4779248 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4749009 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4750629 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4779920 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4748177 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4744727 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4788767 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4783395 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4764710 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL4636709 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL4788473 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL4747995 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL4789491 | — | IC50 | - | — | - | |
| CHEMBL4761407 | — | IC50 | - | — | - | |
| CHEMBL4757898 | — | IC50 | - | — | - | |
| CHEMBL4756334 | — | IC50 | - | — | - | |
| CHEMBL4757764 | — | IC50 | - | — | - | |
| CHEMBL4799199 | — | IC50 | - | — | - | |
| CHEMBL4762148 | — | IC50 | - | — | - | |
| CHEMBL4777112 | — | IC50 | - | — | - | |
| CHEMBL4780616 | — | IC50 | - | — | - | |
| CHEMBL4764265 | — | IC50 | - | — | - |