Assay Detail
Binding
CHEMBL4689686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IDO1 in LPS and IFN-gamma-stimulated human Whole blood assessed as reduction in kynurenine production using isotope-labeled tryptophan as substrate incubated for 15 mins followed by LPS and IFN-gamma stimulation measured after 18 hrs by LC-MS/MS analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.84 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744727 | — | — | 1 | 7.58 |
| CHEMBL4783395 | — | — | 1 | 7.38 |
| CHEMBL4749009 | — | — | 1 | 6.90 |
| CHEMBL4788767 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744727 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4783395 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4749009 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL4788767 | — | IC50 | = | 3249.0 | nM | 5.49 |