Assay Detail
Binding
CHEMBL4699697
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Inhibition of recombinant human MAO-B using p-tyramine as substrate preincubated with enzyme for 15 mins followed incubation with substrate for 20 mins by Amplex red reagent based fluorescence based analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer''s disease
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.02 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4760340 | — | — | 1 | 7.46 |
| CHEMBL673 | PARGYLINE | 4.0 | 1 | 6.92 |
| CHEMBL4762982 | — | — | 1 | 6.57 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.16 |
| CHEMBL4798359 | — | — | 1 | 4.95 |
| CHEMBL4790953 | — | — | 1 | 4.75 |
| CHEMBL4757560 | — | — | 1 | 4.71 |
| CHEMBL4793623 | — | — | 1 | 4.71 |
| CHEMBL4286799 | — | — | 1 | 4.70 |
| CHEMBL4749888 | — | — | 1 | 4.64 |
| CHEMBL4762012 | — | — | 1 | 4.58 |
| CHEMBL4782785 | — | — | 1 | 4.54 |
| CHEMBL4798406 | — | — | 1 | 4.53 |
| CHEMBL4794092 | — | — | 1 | 4.51 |
| CHEMBL4757818 | — | — | 1 | 4.48 |
| CHEMBL4755016 | — | — | 1 | 4.45 |
| CHEMBL4741196 | — | — | 1 | 4.33 |
| CHEMBL4756552 | — | — | 1 | 4.28 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4760340 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL673 | PARGYLINE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4762982 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 6930.0 | nM | 5.16 |
| CHEMBL4798359 | — | IC50 | = | 11230.0 | nM | 4.95 |
| CHEMBL4790953 | — | IC50 | = | 17680.0 | nM | 4.75 |
| CHEMBL4757560 | — | IC50 | = | 19730.0 | nM | 4.71 |
| CHEMBL4793623 | — | IC50 | = | 19460.0 | nM | 4.71 |
| CHEMBL4286799 | — | IC50 | = | 20030.0 | nM | 4.70 |
| CHEMBL4749888 | — | IC50 | = | 22820.0 | nM | 4.64 |
| CHEMBL4762012 | — | IC50 | = | 26130.0 | nM | 4.58 |
| CHEMBL4782785 | — | IC50 | = | 28640.0 | nM | 4.54 |
| CHEMBL4798406 | — | IC50 | = | 29460.0 | nM | 4.53 |
| CHEMBL4794092 | — | IC50 | = | 30930.0 | nM | 4.51 |
| CHEMBL4757818 | — | IC50 | = | 33290.0 | nM | 4.48 |
| CHEMBL4755016 | — | IC50 | = | 35290.0 | nM | 4.45 |
| CHEMBL4741196 | — | IC50 | = | 46270.0 | nM | 4.33 |
| CHEMBL4756552 | — | IC50 | = | 52450.0 | nM | 4.28 |
| CHEMBL502 | DONEPEZIL | IC50 | - | — | - |