Assay Detail
Binding
CHEMBL4699703
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MAO- A using p-tyramine as substrate preincubated with enzyme for 15 mins followed incubation with substrate for 20 mins by Amplex red reagent based fluorescence based analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer''s disease
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.78 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.23 |
| CHEMBL4760340 | — | — | 1 | 4.94 |
| CHEMBL4762982 | — | — | 1 | 4.17 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
| CHEMBL673 | PARGYLINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92401 | IPRONIAZID | IC50 | = | 5890.0 | nM | 5.23 |
| CHEMBL4760340 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL4762982 | — | IC50 | = | 67200.0 | nM | 4.17 |
| CHEMBL502 | DONEPEZIL | IC50 | - | — | - | |
| CHEMBL673 | PARGYLINE | IC50 | - | — | - |