Assay Detail
Functional
CHEMBL4699781
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Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of potent CPP6-gemcitabine conjugates against human prostate cancer cell line (PC-3)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.01 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.85 |
| CHEMBL4764619 | — | — | 1 | 8.40 |
| CHEMBL4800221 | — | — | 1 | 8.29 |
| CHEMBL4796317 | — | — | 1 | 8.16 |
| CHEMBL1431 | METFORMIN | 4.0 | 1 | 8.00 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 7.70 |
| CHEMBL4749693 | — | — | 1 | 6.65 |
| CHEMBL4778383 | — | — | 1 | - |
| CHEMBL4746302 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4764619 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4800221 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4796317 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL1431 | METFORMIN | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4749693 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL4778383 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4746302 | — | IC50 | > | 1000.0 | nM | - |