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Assay Detail

CHEMBL4699933

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human DAN-G cells assessed as reduction in cell viability in presence of Cu2+ incubated for 72 hrs by cell titer-glo luminescent cell viability assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type DAN-G
Confidence 1 — Organism
Curated By Autocuration

Target

DAN-G (CHEMBL614033)
Type CELL-LINE
Organism Homo sapiens

Publication

Isoquinoline thiosemicarbazone displays potent anticancer activity with in vivo efficacy against aggressive leukemias
Sun, Daniel L., Poddar, Soumya, Pan, Roy D., Rosser, Ethan W., Abt, Evan R., Van Valkenburgh, Juno, Le, Thuc M., Lok, Vincent, Hernandez, Selena P., Song, Janet, Li, Joanna, Turlik, Aneta, Chen, Xiaohong, Cheng, Chi-An, Chen, Wei, Mona, Christine E., Stuparu, Andreea D., Vergnes, Laurent, Reue, Karen, Damoiseaux, Robert, Zink, Jeffrey I., Czernin, Johannes, Donahue, Timothy R., Houk, Kendall N., Jung, Michael E., Radu, Caius G.
RSC Med Chem (2020) 11 : 392 -410
PubMed 33479645 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 9.00 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4764390 1 9.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4764390 IC50 = 1.0 nM 9.00