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Assay Detail

CHEMBL4700002

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Dixon plot analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Tissue Liver
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Arginase-1 (CHEMBL1075060)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors
Muller, J., Cardey, B., Zedet, A., Desingle, C., Grzybowski, M., Pomper, P., Foley, S., Harakat, D., Ramseyer, C., Girard, C., Pudlo, M.
RSC Med Chem (2020) 11 : 559 -568
PubMed 33479657 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 4.09 4.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4754674 1 4.09
CHEMBL69863 PICEATANNOL 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4754674 Ki = 82000.0 nM 4.09
CHEMBL69863 PICEATANNOL Ki = 136000.0 nM -