Assay Detail
Binding
CHEMBL4700264
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Covalent inhibition of Trypanosoma cruzi cruzipain using Z-Phe-Arg-7-amidomethylcoumarin as substrate measured after 5 mins by fluorometric analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.28 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4463665 | — | — | 1 | 6.60 |
| CHEMBL344174 | — | — | 1 | 6.30 |
| CHEMBL371466 | — | — | 1 | 6.30 |
| CHEMBL4213247 | — | — | 1 | 5.40 |
| CHEMBL4217658 | — | — | 1 | 5.20 |
| CHEMBL4208861 | — | — | 1 | 5.00 |
| CHEMBL4789329 | — | — | 1 | 5.00 |
| CHEMBL4776689 | — | — | 1 | 5.00 |
| CHEMBL4750144 | — | — | 1 | 4.70 |
| CHEMBL4209401 | — | — | 1 | 4.60 |
| CHEMBL4747490 | — | — | 1 | 4.00 |
| CHEMBL4203721 | — | — | 1 | - |
| CHEMBL4213366 | — | — | 1 | - |
| CHEMBL4208600 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4463665 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL344174 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL371466 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL4213247 | — | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL4217658 | — | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL4208861 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL4789329 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL4776689 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL4750144 | — | Ki | = | 19952.62 | nM | 4.70 |
| CHEMBL4209401 | — | Ki | = | 25118.86 | nM | 4.60 |
| CHEMBL4747490 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL4203721 | — | Ki | = | 199526.23 | nM | - |
| CHEMBL4213366 | — | Ki | = | 125892.54 | nM | - |
| CHEMBL4208600 | — | Ki | = | 398107.17 | nM | - |