Assay Detail
Functional
CHEMBL4700758
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Inhibition of amyloid beta (1 to 42) secretion in human H4 cells overexpressing APP incubated for overnight by HTRF analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H4 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.83 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4794465 | — | — | 1 | 8.70 |
| CHEMBL4209316 | — | — | 1 | 8.18 |
| CHEMBL3769487 | — | — | 1 | 7.51 |
| CHEMBL3769431 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4794465 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4209316 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL3769487 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3769431 | — | IC50 | = | 120.0 | nM | 6.92 |