Assay Detail
Functional
CHEMBL4700879
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Antiproliferative activity against human KOPN-8 cells assessed as growth inhibition after 48 hrs by PrestoBlue dye based fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KOPN-8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Position of lipidation influences anticancer activity of Smac analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.58 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4749062 | — | — | 1 | 6.00 |
| CHEMBL4758982 | — | — | 1 | 6.00 |
| CHEMBL4757749 | — | — | 1 | 5.96 |
| CHEMBL4753399 | — | — | 1 | 5.96 |
| CHEMBL3623511 | — | — | 1 | 5.62 |
| CHEMBL4755167 | — | — | 1 | 5.44 |
| CHEMBL4751547 | — | — | 1 | 5.23 |
| CHEMBL4789627 | — | — | 1 | 5.09 |
| CHEMBL4782637 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4749062 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4758982 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4757749 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4753399 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3623511 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4755167 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4751547 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4789627 | — | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4782637 | — | EC50 | = | 11100.0 | nM | 4.96 |