Assay Detail
Functional
CHEMBL4700892
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Antiproliferative activity against human M229 cells assessed as growth inhibition after 48 hrs by PrestoBlue dye based fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | M229 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Position of lipidation influences anticancer activity of Smac analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.07 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4749062 | — | — | 1 | 5.54 |
| CHEMBL4753399 | — | — | 1 | 5.48 |
| CHEMBL4757749 | — | — | 1 | 5.20 |
| CHEMBL4755167 | — | — | 1 | 5.01 |
| CHEMBL4751547 | — | — | 1 | 4.94 |
| CHEMBL3623511 | — | — | 1 | 4.91 |
| CHEMBL4782637 | — | — | 1 | 4.84 |
| CHEMBL4789627 | — | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4749062 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4753399 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4757749 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4755167 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4751547 | — | EC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL3623511 | — | EC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4782637 | — | EC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL4789627 | — | EC50 | = | 22600.0 | nM | 4.65 |