Assay Detail
Functional
CHEMBL4700909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human T84 cells assessed as growth inhibition after 48 hrs by PrestoBlue dye based fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T84 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Position of lipidation influences anticancer activity of Smac analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.23 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4753399 | — | — | 1 | 5.75 |
| CHEMBL4749062 | — | — | 1 | 5.70 |
| CHEMBL4757749 | — | — | 1 | 5.21 |
| CHEMBL4755167 | — | — | 1 | 5.03 |
| CHEMBL4782637 | — | — | 1 | 4.97 |
| CHEMBL3623511 | — | — | 1 | 4.96 |
| CHEMBL4751547 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4753399 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4749062 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4757749 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4755167 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4782637 | — | EC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL3623511 | — | EC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL4751547 | — | EC50 | = | 11100.0 | nM | 4.96 |