Assay Detail
Functional
CHEMBL4701066
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In vivo inhibition of BTK-dependent B cell activation in TI-2 antigen/ NP-Ficoll-induced DBA1 mouse immunized model assessed as reduction in anti-NP IgM antibody titer administered orally twice daily for 10 days measured post last dose by ELISA
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| ED50 | 1 | - | - |
| EC50 | 1 | 6.80 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744041 | — | — | 2 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744041 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4744041 | — | ED50 | = | 4.4 | mg.kg-1 | - |