Assay Detail
ADMET
CHEMBL4701291
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Cytotoxicity against human PNT1A cells assessed as reduction in cell viability
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PNT1A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 3,5-diaryl isoxazole derivatives as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.07 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4787123 | — | — | 1 | 5.47 |
| CHEMBL4790003 | — | — | 1 | 5.35 |
| CHEMBL4753715 | — | — | 1 | 5.28 |
| CHEMBL4749237 | — | — | 1 | 5.16 |
| CHEMBL4797991 | — | — | 1 | 5.04 |
| CHEMBL4792629 | — | — | 1 | 5.02 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.01 |
| CHEMBL4779017 | — | — | 1 | 4.92 |
| CHEMBL4747928 | — | — | 1 | 4.80 |
| CHEMBL4752896 | — | — | 1 | 4.66 |
| CHEMBL4761925 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4787123 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4790003 | — | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL4753715 | — | IC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL4749237 | — | IC50 | = | 6890.0 | nM | 5.16 |
| CHEMBL4797991 | — | IC50 | = | 9160.0 | nM | 5.04 |
| CHEMBL4792629 | — | IC50 | = | 9510.0 | nM | 5.02 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL4779017 | — | IC50 | = | 11890.0 | nM | 4.92 |
| CHEMBL4747928 | — | IC50 | = | 15740.0 | nM | 4.80 |
| CHEMBL4752896 | — | IC50 | = | 21810.0 | nM | 4.66 |
| CHEMBL4761925 | — | IC50 | = | 117330.0 | nM | - |