Assay Detail
Functional
CHEMBL4701319
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Phototoxicity against human SK-MEL-28 cells assessed as reduction in cell viability preincubated for 16 hrs followed by irradiated with 100 J/cm2 400 to 700 nanometer visible light for 40 mins and measured after 48 hrs by alamar blue assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-28 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Enhanced Production and Anticancer Properties of Photoactivated Perylenequinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.25 | 7.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4796095 | — | — | 1 | 7.99 |
| CHEMBL4793204 | — | — | 1 | 7.83 |
| CHEMBL4792950 | — | — | 1 | 7.27 |
| CHEMBL4748633 | — | — | 1 | 6.87 |
| CHEMBL4786703 | — | — | 1 | 6.76 |
| CHEMBL4787050 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4796095 | — | EC50 | = | 10.3 | nM | 7.99 |
| CHEMBL4793204 | — | EC50 | = | 14.7 | nM | 7.83 |
| CHEMBL4792950 | — | EC50 | = | 53.5 | nM | 7.27 |
| CHEMBL4748633 | — | EC50 | = | 135.0 | nM | 6.87 |
| CHEMBL4786703 | — | EC50 | = | 172.0 | nM | 6.76 |
| CHEMBL4787050 | — | EC50 | = | 176.0 | nM | 6.75 |