Assay Detail
Functional
CHEMBL4701323
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of parasite growth incubated for 72 hrs by DAPI staining based fluorescence analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Prenylated Flavonoids from the Roots of Tephrosia rhodesica.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.90 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 9.17 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.33 |
| CHEMBL4751698 | — | — | 1 | 5.24 |
| CHEMBL4743345 | — | — | 1 | 5.16 |
| CHEMBL4753230 | — | — | 1 | 5.14 |
| CHEMBL4789971 | — | — | 1 | 5.13 |
| CHEMBL4783801 | — | — | 1 | 5.07 |
| CHEMBL4756391 | — | — | 1 | 4.99 |
| CHEMBL4798009 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4751698 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4743345 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4753230 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4789971 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4783801 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4756391 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL4798009 | — | IC50 | = | 14500.0 | nM | 4.84 |