Assay Detail
Binding
CHEMBL4701385
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Inhibition of CDK4 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Developments in the Biology and Medicinal Chemistry of CDK9 Inhibitors: An Update.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.93 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4442620 | RONICICLIB | 2.0 | 1 | 7.96 |
| CHEMBL4741442 | — | — | 1 | 7.21 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.00 |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | 7.00 |
| CHEMBL4755256 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4442620 | RONICICLIB | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4741442 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL445813 | AT-7519 | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4755256 | — | IC50 | = | 3250.0 | nM | 5.49 |