Assay Detail
Binding
CHEMBL4701389
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Inhibition of CDK9 (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Developments in the Biology and Medicinal Chemistry of CDK9 Inhibitors: An Update.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.96 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 8.52 |
| CHEMBL4756595 | ENITOCICLIB | 1.0 | 1 | 8.52 |
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 8.40 |
| CHEMBL4741442 | — | — | 1 | 8.30 |
| CHEMBL4442620 | RONICICLIB | 2.0 | 1 | 8.30 |
| CHEMBL4761602 | — | — | 1 | 8.30 |
| CHEMBL4764173 | — | — | 1 | 7.58 |
| CHEMBL4594423 | TP-1287 | 1.0 | 1 | 7.08 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 6.64 |
| CHEMBL4755256 | — | — | 1 | - |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4756595 | ENITOCICLIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2103840 | DINACICLIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4741442 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4442620 | RONICICLIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4761602 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4764173 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4594423 | TP-1287 | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4755256 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL445813 | AT-7519 | IC50 | < | 10.0 | nM | - |