Assay Detail
Binding
CHEMBL4701727
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Modulation of gamma secretase (unknown origin) assessed as inhibition of amyloid beta (1 to 42 residues) production
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.52 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4209316 | — | — | 1 | 8.40 |
| CHEMBL4757307 | — | — | 1 | 8.30 |
| CHEMBL4753645 | — | — | 1 | 8.00 |
| CHEMBL4757003 | — | — | 1 | 7.85 |
| CHEMBL4782161 | — | — | 1 | 7.77 |
| CHEMBL4793756 | — | — | 1 | 7.50 |
| CHEMBL4780074 | — | — | 1 | 7.22 |
| CHEMBL4795926 | — | — | 1 | 7.02 |
| CHEMBL4763646 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4209316 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4757307 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4753645 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4757003 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4782161 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4793756 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4780074 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4795926 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4763646 | — | IC50 | = | 2300.0 | nM | 5.64 |