Assay Detail

CHEMBL4701893

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity

Toxicity in mouse 3T3 cells under irradiation by NRU phototoxicity test

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Toxicity
Organism	Mus musculus
Cell Type	3T3
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.

LaMarche MJ,Acker M,Argintaru A,Bauer D,Boisclair J,Chan H,Chen CH,Chen YN,Chen Z,Deng Z,Dore M,Dunstan D,Fan J,Fekkes P,Firestone B,Fodor M,Garcia-Fortanet J,Fortin PD,Fridrich C,Giraldes J,Glick M,Grunenfelder D,Hao HX,Hentemann M,Ho S,Jouk A,Kang ZB,Karki R,Kato M,Keen N,Koenig R,LaBonte LR,Larrow J,Liu G,Liu S,Majumdar D,Mathieu S,Meyer MJ,Mohseni M,Ntaganda R,Palermo M,Perez L,Pu M,Ramsey T,Reilly J,Sarver P,Sellers WR,Sendzik M,Shultz MD,Slisz J,Slocum K,Smith T,Spence S,Stams T,Straub C,Tamez V,Toure BB,Towler C,Wang P,Wang H,Williams SL,Yang F,Yu B,Zhang JH,Zhu S
J Med Chem (2020) 63 : 13578 -13594
PubMed 32910655 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	5.07	5.35

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4060033	—	—	1	5.35
CHEMBL4762625	—	—	1	4.79
CHEMBL4650521	BATOPROTAFIB	2.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4060033	—	IC50	=	4500.0	nM	5.35
CHEMBL4762625	—	IC50	=	16200.0	nM	4.79
CHEMBL4650521	BATOPROTAFIB	IC50	=	666000.0	nM	-