Assay Detail
Binding
CHEMBL4701902
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by Q-patch assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.24 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4754023 | — | — | 1 | 5.77 |
| CHEMBL4789106 | — | — | 1 | 5.62 |
| CHEMBL4762625 | — | — | 1 | 5.55 |
| CHEMBL4060033 | — | — | 1 | 5.23 |
| CHEMBL4755819 | — | — | 1 | 5.22 |
| CHEMBL4746224 | — | — | 1 | 5.21 |
| CHEMBL4763213 | — | — | 1 | 4.92 |
| CHEMBL4750422 | — | — | 1 | 4.91 |
| CHEMBL4756767 | — | — | 1 | 4.76 |
| CHEMBL4743002 | — | — | 1 | - |
| CHEMBL4740294 | — | — | 1 | - |
| CHEMBL4747789 | — | — | 1 | - |
| CHEMBL4778151 | — | — | 1 | - |
| CHEMBL4797606 | — | — | 1 | - |
| CHEMBL4784611 | — | — | 1 | - |
| CHEMBL4795635 | — | — | 1 | - |
| CHEMBL4650521 | BATOPROTAFIB | 2.0 | 1 | - |
| CHEMBL4763856 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4754023 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4789106 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4762625 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4060033 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4755819 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4746224 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4763213 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL4750422 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL4756767 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL4743002 | — | IC50 | - | — | - | |
| CHEMBL4740294 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4747789 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4778151 | — | IC50 | - | — | - | |
| CHEMBL4797606 | — | IC50 | - | — | - | |
| CHEMBL4784611 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4795635 | — | IC50 | - | — | - | |
| CHEMBL4650521 | BATOPROTAFIB | IC50 | > | 30000.0 | nM | - |
| CHEMBL4763856 | — | IC50 | - | — | - |