Assay Detail
Functional
CHEMBL4701948
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Antiproliferative activity against HLF1 cells assessed as reduction in TGFbeta-induced cell proliferation measured after 48 hrs by CCK8 assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HLF1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Novel Pyrazolo[3,4-b] Pyridine Derivatives with Dual Activities of Vascular Remodeling Inhibition and Vasodilation for the Treatment of Pulmonary Arterial Hypertension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.32 | 4.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4780823 | — | — | 1 | 4.51 |
| CHEMBL4797223 | — | — | 1 | 4.43 |
| CHEMBL4785559 | — | — | 1 | 4.42 |
| CHEMBL4752923 | — | — | 1 | 4.38 |
| CHEMBL4782536 | — | — | 1 | 4.30 |
| CHEMBL4752719 | — | — | 1 | 4.28 |
| CHEMBL4749361 | — | — | 1 | 4.28 |
| CHEMBL4749124 | — | — | 1 | 4.26 |
| CHEMBL4783763 | — | — | 1 | 4.25 |
| CHEMBL4754851 | — | — | 1 | 4.20 |
| CHEMBL4743189 | — | — | 1 | 4.17 |
| CHEMBL478629 | DORSOMORPHIN | — | 1 | - |
| CHEMBL4764302 | — | — | 1 | - |
| CHEMBL4763850 | — | — | 1 | - |
| CHEMBL4792492 | — | — | 1 | - |
| CHEMBL4784189 | — | — | 1 | - |
| CHEMBL4782618 | — | — | 1 | - |
| CHEMBL4795950 | — | — | 1 | - |
| CHEMBL2107834 | RIOCIGUAT | 4.0 | 1 | - |
| CHEMBL4761659 | — | — | 1 | - |
| CHEMBL4795558 | — | — | 1 | - |
| CHEMBL4745236 | — | — | 1 | - |
| CHEMBL4761150 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4780823 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4797223 | — | IC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL4785559 | — | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL4752923 | — | IC50 | = | 41900.0 | nM | 4.38 |
| CHEMBL4782536 | — | IC50 | = | 49700.0 | nM | 4.30 |
| CHEMBL4752719 | — | IC50 | = | 52800.0 | nM | 4.28 |
| CHEMBL4749361 | — | IC50 | = | 52800.0 | nM | 4.28 |
| CHEMBL4749124 | — | IC50 | = | 55300.0 | nM | 4.26 |
| CHEMBL4783763 | — | IC50 | = | 55600.0 | nM | 4.25 |
| CHEMBL4754851 | — | IC50 | = | 63400.0 | nM | 4.20 |
| CHEMBL4743189 | — | IC50 | = | 67700.0 | nM | 4.17 |
| CHEMBL478629 | DORSOMORPHIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL4764302 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4763850 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4792492 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4784189 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4782618 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4795950 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2107834 | RIOCIGUAT | IC50 | > | 100000.0 | nM | - |
| CHEMBL4761659 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4795558 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4745236 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4761150 | — | IC50 | > | 100000.0 | nM | - |