Assay Detail
Functional
CHEMBL4701960
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Antiproliferative activity against HLF1 cells measured after 48 hrs under hypoxic condition by CCK8 assay
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HLF1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Novel Pyrazolo[3,4-b] Pyridine Derivatives with Dual Activities of Vascular Remodeling Inhibition and Vasodilation for the Treatment of Pulmonary Arterial Hypertension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 2 | - | - |
| IC50 | 1 | 4.46 | 4.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4785559 | — | — | 1 | 4.46 |
| CHEMBL2107834 | RIOCIGUAT | 4.0 | 1 | - |
| CHEMBL478629 | DORSOMORPHIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4785559 | — | IC50 | = | 34900.0 | nM | 4.46 |
| CHEMBL2107834 | RIOCIGUAT | Activity | - | — | - | |
| CHEMBL478629 | DORSOMORPHIN | Activity | - | — | - |