Assay Detail
Binding
CHEMBL4702018
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Inhibition of HDAC in human HeLa nuclear extract using fluoroscence-labeled acetylated peptide as substrate by fluorometric assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Subcellular | Nucleus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of novel indirubin-based N-hydroxybenzamides, N-hydroxypropenamides and N-hydroxyheptanamides as histone deacetylase inhibitors and antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.41 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4788217 | — | — | 1 | 8.52 |
| CHEMBL4746933 | — | — | 1 | 8.40 |
| CHEMBL4791243 | — | — | 1 | 8.30 |
| CHEMBL4781628 | — | — | 1 | 8.30 |
| CHEMBL4756818 | — | — | 1 | 8.15 |
| CHEMBL4781515 | — | — | 1 | 7.85 |
| CHEMBL4745319 | — | — | 1 | 7.75 |
| CHEMBL4793145 | — | — | 1 | 7.70 |
| CHEMBL4783280 | — | — | 1 | 7.68 |
| CHEMBL4761187 | — | — | 1 | 7.66 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.60 |
| CHEMBL4751879 | — | — | 1 | 7.60 |
| CHEMBL4764495 | — | — | 1 | 7.41 |
| CHEMBL4762257 | — | — | 1 | 7.15 |
| CHEMBL4781506 | — | — | 1 | 7.02 |
| CHEMBL4777783 | — | — | 1 | 6.76 |
| CHEMBL4758196 | — | — | 1 | 6.74 |
| CHEMBL4797488 | — | — | 1 | 6.71 |
| CHEMBL4743446 | — | — | 1 | 6.66 |
| CHEMBL4748486 | — | — | 1 | 6.50 |
| CHEMBL4795999 | — | — | 1 | 6.38 |
| CHEMBL4746171 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4788217 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4746933 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4791243 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4781628 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4756818 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4781515 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4745319 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4793145 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4783280 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4761187 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4751879 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4764495 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4762257 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4781506 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4777783 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL4758196 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL4797488 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL4743446 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL4748486 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL4795999 | — | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL4746171 | — | IC50 | = | 604.0 | nM | 6.22 |