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Assay Detail

CHEMBL4702840

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Functional
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by LDH assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes.
Aucamp J,Zuma NH,N'Da DD
Bioorg Med Chem Lett (2020) 30 : 127581 -127581
PubMed 32987134 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 7.79 8.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL307261 ARTENIMOL 3.0 1 8.92
CHEMBL566534 ARTEMETHER 4.0 1 8.64
CHEMBL4796555 1 8.59
CHEMBL4759831 1 8.51
CHEMBL4777912 1 8.39
CHEMBL4748239 1 8.36
CHEMBL4790274 1 8.23
CHEMBL4744949 1 8.16
CHEMBL4764815 1 8.16
CHEMBL4782912 1 8.15
CHEMBL4739985 1 8.15
CHEMBL4743796 1 8.13
CHEMBL207675 SODIUM ARESUNATE 1 8.12
CHEMBL4790814 1 8.11
CHEMBL4740979 1 7.94
CHEMBL4799849 1 7.90
CHEMBL4753333 1 7.45
CHEMBL4783871 1 7.42
CHEMBL4753879 1 7.38
CHEMBL4755475 1 7.37
CHEMBL494952 1 7.09
CHEMBL4747559 1 6.93
CHEMBL4761016 1 6.42
CHEMBL4800683 1 6.37
CHEMBL4765202 1 5.78

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL307261 ARTENIMOL IC50 = 1.2 nM 8.92
CHEMBL566534 ARTEMETHER IC50 = 2.3 nM 8.64
CHEMBL4796555 IC50 = 2.6 nM 8.59
CHEMBL4759831 IC50 = 3.1 nM 8.51
CHEMBL4777912 IC50 = 4.1 nM 8.39
CHEMBL4748239 IC50 = 4.4 nM 8.36
CHEMBL4790274 IC50 = 5.9 nM 8.23
CHEMBL4744949 IC50 = 6.9 nM 8.16
CHEMBL4764815 IC50 = 6.9 nM 8.16
CHEMBL4782912 IC50 = 7.1 nM 8.15
CHEMBL4739985 IC50 = 7.1 nM 8.15
CHEMBL4743796 IC50 = 7.4 nM 8.13
CHEMBL207675 SODIUM ARESUNATE IC50 = 7.5 nM 8.12
CHEMBL4790814 IC50 = 7.8 nM 8.11
CHEMBL4740979 IC50 = 11.5 nM 7.94
CHEMBL4799849 IC50 = 12.6 nM 7.90
CHEMBL4753333 IC50 = 35.3 nM 7.45
CHEMBL4783871 IC50 = 38.5 nM 7.42
CHEMBL4753879 IC50 = 41.3 nM 7.38
CHEMBL4755475 IC50 = 43.2 nM 7.37
CHEMBL494952 IC50 = 80.7 nM 7.09
CHEMBL4747559 IC50 = 116.7 nM 6.93
CHEMBL4761016 IC50 = 384.0 nM 6.42
CHEMBL4800683 IC50 = 429.9 nM 6.37
CHEMBL4765202 IC50 = 1672.2 nM 5.78