Assay Detail
Binding
CHEMBL4703073
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DHODH
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A carboxylic acid isostere screen of the DHODH inhibitor Brequinar.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.43 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744558 | — | — | 1 | 9.92 |
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 9.32 |
| CHEMBL4759615 | — | — | 1 | 8.85 |
| CHEMBL4797708 | — | — | 1 | 8.38 |
| CHEMBL4759152 | — | — | 1 | 8.11 |
| CHEMBL4762268 | — | — | 1 | 7.50 |
| CHEMBL4760819 | — | — | 1 | 7.33 |
| CHEMBL4785347 | — | — | 1 | 7.13 |
| CHEMBL4743387 | — | — | 1 | 6.94 |
| CHEMBL4748668 | — | — | 1 | 6.80 |
| CHEMBL4799525 | — | — | 1 | 6.78 |
| CHEMBL4788745 | — | — | 1 | 6.65 |
| CHEMBL4793693 | — | — | 1 | 6.09 |
| CHEMBL4758872 | — | — | 1 | 5.90 |
| CHEMBL4763950 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744558 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL38434 | BREQUINAR | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL4759615 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4797708 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4759152 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4762268 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4760819 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4785347 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4743387 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL4748668 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4799525 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL4788745 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL4793693 | — | IC50 | = | 808.0 | nM | 6.09 |
| CHEMBL4758872 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4763950 | — | IC50 | = | 1560.0 | nM | 5.81 |