Assay Detail
Binding
CHEMBL4703324
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST-tagged recombinant human full length MNK2 expressed in baculovirus expression system incubated for 1 hr by Kinase Tracer 236 based LanthaScreen Eu kinase binding assay relative to control
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
MAP kinase-interacting serine/threonine-protein kinase 2 (CHEMBL4204) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Biological Evaluation of Selected Flavonoids as Inhibitors of MNKs Targeting Acute Myeloid Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.80 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293776 | HISPIDULIN | — | 1 | 6.60 |
| CHEMBL28 | APIGENIN | — | 1 | 6.51 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 6.24 |
| CHEMBL210635 | GENKWANIN | — | 1 | 6.01 |
| CHEMBL77588 | — | — | 1 | 5.77 |
| CHEMBL4097277 | — | — | 1 | 5.43 |
| CHEMBL4747606 | — | — | 1 | 5.33 |
| CHEMBL4740978 | — | — | 1 | 5.19 |
| CHEMBL4755408 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293776 | HISPIDULIN | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL28 | APIGENIN | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 579.0 | nM | 6.24 |
| CHEMBL210635 | GENKWANIN | IC50 | = | 979.0 | nM | 6.01 |
| CHEMBL77588 | — | IC50 | = | 1703.0 | nM | 5.77 |
| CHEMBL4097277 | — | IC50 | = | 3697.0 | nM | 5.43 |
| CHEMBL4747606 | — | IC50 | = | 4672.0 | nM | 5.33 |
| CHEMBL4740978 | — | IC50 | = | 6486.0 | nM | 5.19 |
| CHEMBL4755408 | — | IC50 | = | 8262.0 | nM | 5.08 |