Assay Detail

CHEMBL4703497

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Binding

Binding affinity to 5HT2C (unknown origin)

ChEMBL ↗

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Target

5-hydroxytryptamine receptor 2C (CHEMBL225) ↗

Open DB target context

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5-hydroxytryptamine receptor 2C (CHEMBL225) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target 5-hydroxytryptamine receptor 2C

CHEMBL225

Anchored from Assay target.

Protein identity 5-hydroxytryptamine receptor 2C

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

5-hydroxytryptamine receptor 2C (CHEMBL225) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Structure activity relationship of novel antiviral nucleosides against Enterovirus A71.

Tosh DK,Toti KS,Hurst BL,Julander JG,Jacobson KA
Bioorg Med Chem Lett (2020) 30 : 127599 -127599
PubMed 33031923 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	6.77	6.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4743059	—	—	1	6.77
CHEMBL4744176	—	—	1	6.77

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4743059	—	Ki	=	170.0	nM	6.77
CHEMBL4744176	—	Ki	=	170.0	nM	6.77