Assay Detail
Binding
CHEMBL4703740
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Reversible inhibition of SARS coronavirus Urbani 3CL protease(9985 to 10902) using TAMRA-SITSAVLQSGFRKMK(DABCYL)-OH as substrate measured for 10 mins by FRET assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | SARS coronavirus Urbani |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.30 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4777223 | PF-00835231 | -1.0 | 1 | 8.40 |
| CHEMBL4756136 | — | — | 1 | 8.15 |
| CHEMBL4747979 | — | — | 1 | 7.70 |
| CHEMBL4754028 | — | — | 1 | 7.70 |
| CHEMBL4763680 | — | — | 1 | 7.47 |
| CHEMBL4763264 | — | — | 1 | 7.46 |
| CHEMBL4783620 | — | — | 1 | 7.42 |
| CHEMBL4797483 | — | — | 1 | 7.36 |
| CHEMBL4785436 | — | — | 1 | 7.28 |
| CHEMBL4740807 | — | — | 1 | 7.08 |
| CHEMBL4740540 | — | — | 1 | 7.04 |
| CHEMBL4764415 | — | — | 1 | 6.99 |
| CHEMBL4759976 | — | — | 1 | 6.98 |
| CHEMBL4787711 | — | — | 1 | 6.95 |
| CHEMBL4743032 | — | — | 1 | 6.88 |
| CHEMBL4750381 | — | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4777223 | PF-00835231 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4756136 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4747979 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4754028 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4763680 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4763264 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4783620 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4797483 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4785436 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4740807 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4740540 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL4764415 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL4759976 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL4787711 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4743032 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL4750381 | — | IC50 | = | 1076.0 | nM | 5.97 |