Assay Detail
Binding
CHEMBL4703744
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-CoV-2 3CL protease using DABCYLKTSAVLQ-SGFRKME-EDANS as peptide substrate in presence of PF-00835231 inhibitor incubated for 60 mins by FRET assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 9.57 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4777223 | PF-00835231 | -1.0 | 1 | 9.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4777223 | PF-00835231 | IC50 | = | 0.27 | nM | 9.57 |