Assay Detail
Functional
CHEMBL4704835
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Cytotoxicity against human PC-3 cells assessed as cell growth inhibition
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of indolylglyoxylamide bisphosphonates, antimitotic microtubule-targeting derivatives of indibulin with improved aqueous solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.55 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49642 | INDIBULIN | 2.0 | 1 | 7.40 |
| CHEMBL267099 | TUBERCIDIN | — | 1 | 7.12 |
| CHEMBL4753750 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49642 | INDIBULIN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL267099 | TUBERCIDIN | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4753750 | — | IC50 | = | 7540.0 | nM | 5.12 |