Assay Detail
Binding
CHEMBL4704897
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at GAL4-tagged PPARalpha-LBD (unknown origin) expressed in HEK293 cells assessed as induction of receptor transactivation incubated for 16 hrs by luciferase reporter gene assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor γ Binding Properties and Biological Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.16 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21241 | GW7647 | — | 1 | 8.27 |
| CHEMBL4743677 | — | — | 1 | 5.72 |
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 1 | 4.50 |
| CHEMBL4741141 | — | — | 1 | - |
| CHEMBL4795671 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21241 | GW7647 | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4743677 | — | EC50 | = | 1882.0 | nM | 5.72 |
| CHEMBL264374 | BEZAFIBRATE | EC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL4741141 | — | EC50 | - | — | - | |
| CHEMBL4795671 | — | EC50 | - | — | - |