Assay Detail
Binding
CHEMBL4705014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using PEA as substrate in presence of 100 uM AdoMet as co-substrate by Sigma-plot analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phenylethanolamine N-methyltransferase (CHEMBL4617) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Drug Design of Bisubstrate Inhibitors of Phenylethanolamine N-Methyltransferase Possessing Low Nanomolar Affinity at Both Substrate Binding Domains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.12 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4764318 | — | — | 1 | 8.68 |
| CHEMBL4751862 | — | — | 1 | 8.49 |
| CHEMBL4782649 | — | — | 1 | 8.48 |
| CHEMBL4760727 | — | — | 1 | 8.46 |
| CHEMBL4800292 | — | — | 1 | 8.42 |
| CHEMBL4754656 | — | — | 1 | 8.41 |
| CHEMBL4749263 | — | — | 1 | 7.75 |
| CHEMBL4740168 | — | — | 1 | 7.42 |
| CHEMBL4795252 | — | — | 1 | 7.34 |
| CHEMBL4796664 | — | — | 1 | 7.24 |
| CHEMBL4789060 | — | — | 1 | 7.16 |
| CHEMBL4791266 | — | — | 1 | 7.15 |
| CHEMBL4791373 | — | — | 1 | 7.07 |
| CHEMBL4787632 | — | — | 1 | 6.09 |
| CHEMBL4754362 | — | — | 1 | 5.37 |
| CHEMBL4783068 | — | — | 1 | 5.29 |
| CHEMBL418052 | S-ADENOSYLHOMOCYSTEINE | — | 1 | 4.85 |
| CHEMBL563938 | — | — | 1 | 4.55 |
| CHEMBL59441 | — | — | 1 | - |
| CHEMBL60724 | — | — | 1 | - |
| CHEMBL4749860 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4764318 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL4751862 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL4782649 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL4760727 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL4800292 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL4754656 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL4749263 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL4740168 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL4795252 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL4796664 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL4789060 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL4791266 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL4791373 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL4787632 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL4754362 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL4783068 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL418052 | S-ADENOSYLHOMOCYSTEINE | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL563938 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL59441 | — | Ki | - | — | - | |
| CHEMBL60724 | — | Ki | - | — | - | |
| CHEMBL4749860 | — | Ki | - | — | - |